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Article

Early-phenotype CAR-T cells for the treatment of pediatric cancers.

Annals of oncology : official journal of the European Society for Medical Oncology - 1 Nov 2021

Meyran D, Terry R L, Zhu J J, Haber M, Ziegler D S, Ekert P G, Trapani J A, Darcy P K, Neeson P J

Abstract excerpt

Chimeric antigen receptor (CAR)-T-cell therapy is a promising approach for the treatment of childhood cancers, particularly high-risk tumors that fail to respond to standard therapies. CAR-T cells have been highly successful in treating some types of hematological malignancies. However, CAR-T cells targeting solid cancers have had limited success so far for multiple reasons, including their poor long-term...

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Identifiers

PMID: 34375680
DOI: 10.1016/j.annonc.2021.07.018

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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