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Article

Associations of Homocysteine Metabolism With the Risk of Spinal Osteoarthritis Progression in Postmenopausal Women.

The Journal of clinical endocrinology and metabolism - 19 Nov 2021

Nakano Masaki, Nakamura Yukio, Urano Tomohiko, Miyazaki Akiko, Suzuki Takako, Watanabe Kazuki, Takahashi Jun, Shiraki Masataka

Abstract excerpt

CONTEXT: Although homocysteine accumulation is a reported risk factor for several age-related disorders, little is known about its relationship with osteoarthritis (OA). OBJECTIVE: We investigated for associations of homocysteine and C677T polymorphism in methylenetetrahydrofolate reductase (MTHFR), which is involved in homocysteine clearance, with the development and progression of spinal OA through a combined...

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Identifiers

PMID: 34375425
DOI: 10.1210/clinem/dgab591

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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