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Article

Plasma total homocysteine level and methylenetetrahydrofolate reductase 677C>T genetic polymorphism in Japanese patients with rheumatoid arthritis.

Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals - 1 Feb 2009

Fujimaki Chihiro, Hayashi Hideki, Tsuboi Seiji, Matsuyama Taiji, Kosuge Kazuhiro, Yamada Hiroshi, Inoue Kazuyuki, Itoh Kunihiko

Abstract excerpt

Hyperhomocysteinemia is a known risk factor of cardiovascular disease. Homocysteine has been also linked to inflammation in rheumatoid arthritis (RA). In this study, we investigated the relationship between plasma homocysteine levels and single nucleotide polymorphism (SNP) of the gene coding for methylenetetrahydrofolate reductase (MTHFR), an enzyme involved in the biosynthesis of homocysteine, and the...

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Identifiers

PMID: 19283524
DOI: 10.1080/13547500902730664

Genes

MTHFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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