Article
Calcium signaling mediates the response to cadmium toxicity in Saccharomyces cerevisiae cells.
FEBS letters - 25 Aug 2014
Ruta Lavinia L, Popa Valentina C, Nicolau Ioana, Danet Andrei F, Iordache Virgil, Neagoe Aurora D, Farcasanu Ileana C
Abstract excerpt
The involvement of Ca(2+) in the response to high Mn(2+), Co(2+), Ni(2+), Cu(2+), Zn(2+), Cd(2+), and Hg(2+) was investigated in Saccharomyces cerevisiae. The yeast cells responded through a sharp increase in cytosolic Ca(2+) when exposed to Cd(2+), and to a lesser extent to Cu(2+), but not to Mn(2+), Co(2+), Ni(2+), Zn(2+), or Hg(2+). The response to high Cd(2+) depended mainly on external Ca(2+) (transported...
Topics
- Biological Transport
- Cadmium
- Calcium
- Calcium Signaling
- Cation Transport Proteins
- Cell Membrane
- Copper Transport Proteins
- Cytosol
- Dose-Response Relationship, Drug
- Environmental Pollutants
- Homeostasis
- Iron-Binding Proteins
- Mutation
- Oxidative Stress