Disulfide stress-induced aluminium toxicity: molecular insights through genome-wide screening of Saccharomyces cerevisiae.

doi:10.1039/c3mt00083d

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Article

Disulfide stress-induced aluminium toxicity: molecular insights through genome-wide screening of Saccharomyces cerevisiae.

Metallomics : integrated biometal science - 1 Aug 2013

Tun Nay M, O'Doherty Patrick J, Perrone Gabriel G, Bailey Trevor D, Kersaitis Cindy, Wu Ming J

Abstract excerpt

Formation of non-native disulfide bonds within or between proteins can lead to protein misfolding and disruption to cellular metabolism. Such a process is defined as disulfide stress. A marked effect of disulfide stress in cells is the elevated accumulation of the intracellular aluminium ion (Al(3+)) accompanied by increased cytotoxicity. To gain an in-depth understanding of the underlying molecular mechanism for...

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PMID: 23832094
DOI: 10.1039/c3mt00083d

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.