Article
Practical Considerations for Using RNA Sequencing in Management of B-Lymphoblastic Leukemia: Malaysia-Singapore Acute Lymphoblastic Leukemia 2020 Implementation Strategy.
The Journal of molecular diagnostics : JMD - 1 Oct 2021
Ni Chin Winnie Hui, Li Zhenhua, Jiang Nan, Lim Evelyn Huizi, Suang Lim Joshua Yew, Lu Yi, Chiew Kean Hui, Yin Kham Shirley Kow, Zhi Oh Bernice Ling, Tan Ah Moy, Ariffin Hany, Yang Jun J, Eng-Juh Yeoh Allen
Abstract excerpt
Despite the immense genetic heterogeneity of B-lymphoblastic leukemia [or precursor B-cell acute lymphoblastic leukemia (B-ALL)], RNA sequencing (RNA-Seq) could comprehensively interrogate its genetic drivers, assigning a specific molecular subtype in >90% of patients. However, study groups have only started to use RNA-Seq. For broader clinical use, technical, quality control, and appropriate performance...
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