Article
Mutations in L-type amino acid transporter-2 support SLC7A8 as a novel gene involved in age-related hearing loss.
eLife - 22 Jan 2018
Espino Guarch Meritxell, Font-Llitjós Mariona, Murillo-Cuesta Silvia, Errasti-Murugarren Ekaitz, Celaya Adelaida M, Girotto Giorgia, Vuckovic Dragana, Mezzavilla Massimo, Vilches Clara, Bodoy Susanna, Sahún Ignasi, González Laura, Prat Esther, Zorzano Antonio, Dierssen Mara, Varela-Nieto Isabel, Gasparini Paolo, Palacín Manuel, Nunes Virginia
Abstract excerpt
Age-related hearing loss (ARHL) is the most common sensory deficit in the elderly. The disease has a multifactorial etiology with both environmental and genetic factors involved being largely unknown. SLC7A8/SLC3A2 heterodimer is a neutral amino acid exchanger. Here, we demonstrated that SLC7A8 is expressed in the mouse inner ear and that its ablation resulted in ARHL, due to the damage of different cochlear...
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