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Article

Analysis of Concurrent Intracholecystic Papillary Neoplasms and Biliary Intraepithelial Neoplasia Reveals Distinct Histologic and Molecular Profiles.

Archives of pathology & laboratory medicine - 1 Nov 2025

Malik Preeti, Krishnamurthy Kritika, Sheikh Fahad N, Goldstein Doctor Yitzchak, Panarelli Nicole C

Abstract excerpt

CONTEXT.—: Intracholecystic papillary neoplasms (ICPNs) and biliary intraepithelial neoplasia (BilIN) are presumed precursors to gallbladder adenocarcinomas, but their relationship is incompletely understood. OBJECTIVE.—: To perform morphologic and molecular characterization of concurrent ICPNs, nonpolypoid mucosa, and adenocarcinomas to determine whether these lesions are related at the DNA level. DESIGN.—:...

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Source

Identifiers

PMID: 40203438
DOI: 10.5858/arpa.2024-0340-OA

Genes

APC
KRAS
PIK3CA
RB1
TP53
CTNNB1

Provenance

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