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Article

Investigation of RNA metabolism through large-scale genetic interaction profiling in yeast.

Nucleic acids research - 7 Sept 2021

Decourty Laurence, Malabat Christophe, Frachon Emmanuel, Jacquier Alain, Saveanu Cosmin

Abstract excerpt

Gene deletion and gene expression alteration can lead to growth defects that are amplified or reduced when a second mutation is present in the same cells. We performed 154 genetic interaction mapping (GIM) screens with query mutants related with RNA metabolism and estimated the growth rates of about 700 000 double mutant Saccharomyces cerevisiae strains. The tested targets included the gene deletion collection...

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Identifiers

PMID: 34358317
DOI: 10.1093/nar/gkab680
PMCID: PMC8421204

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