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Article

The RNA-binding protein and stress granule component ATAXIN-2 is expressed in mouse and human tissues associated with glaucoma pathogenesis.

The Journal of comparative neurology - 1 Feb 2022

Sundberg Chad A, Lakk Monika, Paul Sharan, P Figueroa Karla, Scoles Daniel R, Pulst Stefan M, Križaj David

Abstract excerpt

Polyglutamine repeat expansions in the Ataxin-2 (ATXN2) gene were first implicated in Spinocerebellar Ataxia Type 2, a disease associated with degeneration of motor neurons and Purkinje cells. Recent studies linked single nucleotide polymorphisms in the gene to elevated intraocular pressure in primary open angle glaucoma (POAG); yet, the localization of ATXN2 across glaucoma-relevant tissues of the vertebrate eye...

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Identifiers

PMID: 34350994
DOI: 10.1002/cne.25228
PMCID: PMC8716417

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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