Article
A missense mutation in Pitx2 leads to early-onset glaucoma via NRF2-YAP1 axis.
Cell death & disease - 29 Oct 2021
Yang Yeming, Li Xiao, Wang Jieping, Tan Junkai, Fitzmaurice Bernie, Nishina Patsy M, Sun Kuanxiang, Tian Wanli, Liu Wenjing, Liu Xuyang, Chang Bo, Zhu Xianjun
Abstract excerpt
Glaucoma is a leading cause of blindness, affecting 70 million people worldwide. Owing to the similarity in anatomy and physiology between human and mouse eyes and the ability to genetically manipulate mice, mouse models are an invaluable resource for studying mechanisms underlying disease phenotypes and for developing therapeutic strategies. Here, we report the discovery of a new mouse model of early-onset...
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