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Article

A widespread single amino acid mutation in AcrA reduces tigecycline susceptibility in Klebsiella pneumoniae.

Microbiology spectrum - 11 Jan 2024

Xu Yingchao, Wang Wenjia, Su Wenya, Wang Mingyu, Xu Hai, Zhang Xuhua, Li Ling

Abstract excerpt

IMPORTANCE: Tigecycline, a glycecycline antibiotic with broad-spectrum activity against almost all Gram-positive and Gram-negative bacteria, is a highly concerned "last-resort" antibiotic. In addition to plasmid-hosted mobile tet(X) conferring high-level resistance to tigecycline, there are many reports suggesting increased expression of AcrAB-TolC efflux pump leads to tigecycline non-susceptibility. However, the...

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Identifiers

PMID: 38032193
DOI: 10.1128/spectrum.02030-23
PMCID: PMC10782974

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A widespread single amino acid mutation in AcrA reduces tigecycline susceptibility in Klebsiella pneumoniae.PMID 38032193Read ↗

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