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Article

Blocking MCT4 SUMOylation inhibits the growth of breast cancer cells.

Molecular carcinogenesis - 1 Oct 2021

Hu Xiao, Liu Zhanzhao, Duan Xianxian, Han Xiao, Yuan Mengci, Liu Lingyan, Xia Xiaojun, Li Ning, Qin Junfang, Wang Yue

Abstract excerpt

Monocarboxylate transporter 4 (MCT4) is highly expressed in various types of solid neoplasms including breast cancer (BC); however, the pro-tumor functions underlying its increased expression have not been explained. Here, we examined the roles of posttranslational modifications to MCT4 in BC, particularly SUMOylation. Our findings revealed that SUMOylation of MCT4 inhibited its degradation and stabilized MCT4...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34347919
DOI: 10.1002/mc.23336

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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