Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Crystal structures of human tissue kallikrein 4: activity modulation by a specific zinc binding site.

Journal of molecular biology - 6 Oct 2006

Debela Mekdes, Magdolen Viktor, Grimminger Valerie, Sommerhoff Christian, Messerschmidt Albrecht, Huber Robert, Friedrich Rainer, Bode Wolfram, Goettig Peter

Abstract excerpt

Human tissue kallikrein 4 (hK4) belongs to a 15-member family of closely related serine proteinases. hK4 is predominantly expressed in prostate, activates hK3/PSA, and is up-regulated in prostate and ovarian cancer. We have identified active monomers of recombinant hK4 besides inactive oligomers in solution. hK4 crystallised in the presence of zinc, nickel, and cobalt ions in three crystal forms containing cyclic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Crystallization
Share to Hydrogen-Ion Concentration

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Inhibitory Concentration 50

Share to Kallikreins

Share to Molecular Weight

Share to Solutions

Share to X-Ray Diffraction

Source

Identifiers

PMID: 16950394
DOI: 10.1016/j.jmb.2006.08.003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Crystal structures of human tissue kallikrein 4: activity modulation by a specific zinc binding site.PMID 16950394Read ↗

Structure-function analyses of human kallikrein-related peptidase 2 establish the 99-loop as master regulator of activity.Semantic proximity Read ↗

Human Tissue Kallikrein 5 Is a Member of a Proteolytic Cascade Pathway Involved in Seminal Clot Liquefaction and Potentially in Prostate Cancer ProgressionSemantic proximity Read ↗

The New Human Tissue Kallikrein Gene Family: Structure, Function, and Association to Disease*Semantic proximity Read ↗

Structural studies of complexes of kallikrein 4 with wild-type and mutated forms of the Kunitz-type inhibitor BbKI.Semantic proximity Read ↗

Structural Model of Human PSA: A Target for Prostate Cancer TherapySemantic proximity Read ↗

The emerging roles of human tissue kallikreins in cancerSemantic proximity Read ↗

Human prostate-specific glandular kallikrein is expressed as an active and an inactive protein.Semantic proximity Read ↗

Structural basis for Ca(2+)-induced activation of human PAD4.Semantic proximity Read ↗

Substrate specificity of human kallikreins 1 and 6 determined by phage displaySemantic proximity Read ↗

Kallikrein 4 is a Predominantly Nuclear Protein and Is Overexpressed in Prostate CancerSemantic proximity Read ↗

Inhibition profiles of human tissue kallikreins by serine protease inhibitorsSemantic proximity Read ↗

Roles of the P1, P2, and P3 residues in determining inhibitory specificity of kallistatin toward human tissue kallikrein.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.