Article
The prognostic value of BRAF mutation in colorectal cancer and melanoma: a systematic review and meta-analysis.
PloS one - 1 Jan 2012
Safaee Ardekani Gholamreza, Jafarnejad Seyed Mehdi, Tan Larry, Saeedi Ardavan, Li Gang
Abstract excerpt
BACKGROUND: Mutation of BRAF is a predominant event in cancers with poor prognosis such as melanoma and colorectal cancer. BRAF mutation leads to a constitutive activation of mitogen activated protein kinase pathway which is essential for cell proliferation and tumor progression. Despite tremendous efforts made to target BRAF for cancer treatment, the correlation between BRAF mutation and patient survival is...
Topics
- Colorectal Neoplasms
- Confidence Intervals
- Humans
- Melanoma
- Mutation
- Prognosis
- Proto-Oncogene Proteins B-raf