BRAF + EGFR +/- MEK inhibitors after immune checkpoint inhibitors in BRAF V600E mutated and deficient mismatch repair or microsatellite instability high metastatic colorectal cancer.

doi:10.1016/j.ejca.2024.114290

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Article

BRAF + EGFR +/- MEK inhibitors after immune checkpoint inhibitors in BRAF V600E mutated and deficient mismatch repair or microsatellite instability high metastatic colorectal cancer.

European journal of cancer (Oxford, England : 1990) - 1 Oct 2024

Ambrosini Margherita, Tougeron David, Modest Dominik, Guimbaud Rosine, Kopetz Scott, Decraecker Marie, Kim Stefano, Coutzac Clelia, Perkins Geraldine, Alouani Emily, Marmorino Federica, Pernot Simon, Sinicrope Frank A, Elez Elena, Parent Pauline, Cremolini Chiara, Pietrantonio Filippo, Lonardi Sara, Gallois Claire, Taieb Julien

Abstract excerpt

BACKGROUND: Immune checkpoint inhibitors (ICIs) are the guideline endorsed first choice for patients with deficient mismatch repair or microsatellite instability high (dMMR/MSI-H) mCRC, however a significant proportion experience primary or secondary resistance. BRAF V600E mutated (BRAFm) and dMMR/MSI-H mCRC can be treated with BRAF + EGFR inhibitors but specific data on the efficacy after progression to ICIs are...

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PMID: 39216175
DOI: 10.1016/j.ejca.2024.114290

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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