Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Role of Toll-Like Receptor-2 in Clostridioides difficile Infection: Evidence From a Mouse Model and Clinical Patients.

Frontiers in immunology - 1 Jan 2021

Lai Yi-Hsin, Tsai Bo-Yang, Hsu Chih-Yu, Chen Yi-Hsuan, Chou Po-Han, Chen Yueh-Lin, Liu Hsiao-Chieh, Ko Wen-Chien, Tsai Pei-Jane, Hung Yuan-Pin

Abstract excerpt

Background: Clostridioides difficile is the leading cause of nosocomial infectious diarrhea. Toll-like receptors (TLRs) are the major components of innate immunity that sense pathogens. The relationship between TLRs and C. difficile infection (CDI) was analyzed in clinical patients and a mouse model. Materials and Methods: A prospective investigation was conducted in medical wards of Tainan Hospital, Ministry of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Asian People
Share to Clostridioides difficile

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Clostridium Infections

Share to Disease Models, Animal

Share to Mice, Knockout

Share to Toll-Like Receptor 2

Share to Toll-Like Receptor 4

Source

Open in PubMed Open full text

Identifiers

PMID: 34322122
DOI: 10.3389/fimmu.2021.691039
PMCID: PMC8313301

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Role of Toll-Like Receptor-2 in Clostridioides difficile Infection: Evidence From a Mouse Model and Clinical Patients.PMID 34322122Read ↗

Pro-inflammatory Pathways Contribute to Pathogenesis of <i>Clostridioides difficile</i> Infection in a Murine Model - A Spatial Transcriptomics StudySemantic proximity Read ↗

Prevalence and molecular characterization of Clostridioides difficile infection in China over the past 5 years: a systematic review and meta-analysis.Semantic proximity Read ↗

Intestinal inflammation and altered gut microbiota associated with inflammatory bowel disease renders mice susceptible to <i>Clostridioides difficile</i> colonization and infectionSemantic proximity Read ↗

Binary toxin expression by <i>Clostridioides difficile</i> is associated with worse diseaseSemantic proximity Read ↗

The importance of Toll-like receptor 2 polymorphisms in severe infections.Semantic proximity Read ↗

A Mouse Model of Clostridium difficile–Associated DiseaseSemantic proximity Read ↗

Association between TLR2 and TLR4 Gene Polymorphisms and the Susceptibility to Inflammatory Bowel Disease: A Meta-Analysis.Semantic proximity Read ↗

Risk factors for Clostridioides difficile infection and colonization among patients admitted to an intensive care unit in Shanghai, China.Semantic proximity Read ↗

MicroRNA miR-27a-5p Reduces Intestinal Inflammation Induced by Clostridioides difficile Flagella by Regulating the Nuclear Factor–κB Signaling PathwaySemantic proximity Read ↗

Functional analyses of epidemic Clostridioides difficile toxin B variants reveal their divergence in utilizing receptors and inducing pathology.Semantic proximity Read ↗

<i>Clostridioides difficile</i> Toxins Alter Host Metabolic Pathway and Bile Acid Homeostasis Gene Expression In Colonic EpitheliumSemantic proximity Read ↗

A MyD88-deficient mouse model reveals a role for Nramp1 in Campylobacter jejuni infection.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.