Article
Loss of parkin promotes lipid rafts-dependent endocytosis through accumulating caveolin-1: implications for Parkinson's disease.
Molecular neurodegeneration - 1 Dec 2015
Cha Seon-Heui, Choi Yu Ree, Heo Cheol-Ho, Kang Seo-Jun, Joe Eun-Hye, Jou Ilo, Kim Hwan-Myung, Park Sang Myun
Abstract excerpt
BACKGROUND: Parkinson's disease (PD) is characterized by progressive loss of midbrain dopaminergic neurons, resulting in motor dysfunctions. While most PD is sporadic in nature, a significant subset can be linked to either autosomal dominant or recessive mutations. PARK2, encoding the E3 ubiquitin ligase, parkin, is the most frequently mutated gene in autosomal recessive early onset PD. It has recently been...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.