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Article

Epi-mutations for spermatogenic defects by maternal exposure to di(2-ethylhexyl) phthalate.

eLife - 28 Jul 2021

Tando Yukiko, Hiura Hitoshi, Takehara Asuka, Ito-Matsuoka Yumi, Arima Takahiro, Matsui Yasuhisa

Abstract excerpt

Exposure to environmental factors during fetal development may lead to epigenomic modifications in fetal germ cells, altering gene expression and promoting diseases in successive generations. In mouse, maternal exposure to di(2-ethylhexyl) phthalate (DEHP) is known to induce defects in spermatogenesis in successive generations, but the mechanism(s) of impaired spermatogenesis are unclear. Here, we showed that...

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Identifiers

PMID: 34319233
DOI: 10.7554/eLife.70322
PMCID: PMC8318585

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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