Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic variants (LhcgrW495X/+) and environmental toxicants (DEHP) synergistically induce DSD by interfering with steroidogenic gene expression.

Biology of sex differences - 26 Sept 2025

Qigen Xie, Kai Xia, Haiming Cao, Zhe Xu, Yong Gao, Chunhua Deng

Abstract excerpt

BACKGROUND: Emerging evidence suggests that genetic variants and environmental toxicants may synergistically contribute to DSD. To test this hypothesis, we employed LhcgrW495X/+ (luteinizing hormone/chorionic gonadotropin receptor) male mice subjected to prenatal Di-(2-ethylhexyl) phthalate (DEHP) exposure, a model designed to investigate steroidogenic gene expression in gene-environment interactions. METHODS:...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Disorders of Sex Development
Share to Gene-Environment Interaction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Inbred C57BL

Share to Pregnancy

Share to Prenatal Exposure Delayed Effects

Share to Receptors, LH

Share to Testosterone

Source

Open in PubMed Open full text

Identifiers

PMID: 41013757
DOI: 10.1186/s13293-025-00753-0
PMCID: PMC12465185

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic variants (LhcgrW495X/+) and environmental toxicants (DEHP) synergistically induce DSD by interfering with steroidogenic gene expression.PMID 41013757Read ↗

Endocrine-disrupting chemicals (EDCs) and epigenetic regulation in embryonic development: Mechanisms, impacts, and emerging trendsSemantic proximity Read ↗

Testicular Dysgenesis Syndrome and Long-Lasting Epigenetic Silencing of Mouse Sperm Genes Involved in the Reproductive System after Prenatal Exposure to DEHPSemantic proximity Read ↗

Genetic resistance to DEHP-induced transgenerational endocrine disruptionSemantic proximity Read ↗

Impact of Endocrine Disruptors upon Non-Genetic InheritanceSemantic proximity Read ↗

Endocrine disruptors, gene deregulation and male germ cell tumorsSemantic proximity Read ↗

Spermatogenesis disruption by dioxins: Epigenetic reprograming and windows of susceptibilitySemantic proximity Read ↗

Parental occupational exposure to endocrine disrupting chemicals and male genital malformations: A study in the danish national birth cohort studySemantic proximity Read ↗

Epi-mutations for spermatogenic defects by maternal exposure to di(2-ethylhexyl) phthalate.Semantic proximity Read ↗

Gestational exposure to chlordecone promotes transgenerational changes in the murine reproductive system of malesSemantic proximity Read ↗

Epi-mutations for spermatogenic defects by maternal exposure to Di (2-ethylhexyl) phthalateSemantic proximity Read ↗

Exposure to environmental doses of DEHP causes phenotypes of polycystic ovary syndrome.Semantic proximity Read ↗

Multigenerational and transgenerational effects of endocrine disrupting chemicals: A role for altered epigenetic regulation?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.