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Human cytomegalovirus forms phase-separated compartments at viral genomes to facilitate viral replication

1 Mar 2022

Abstract excerpt

Human cytomegalovirus (HCMV) replicates its DNA genome in specialized replication compartments (RCs) in the host cell nucleus. These membrane-less organelles originate as spherical structures and grow in size over time. However, the mechanism of RC biogenesis has remained understudied. Using live-cell imaging and photo-oligomerization, we show that a central component of RCs, the UL112-113 proteins, undergo...

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PMID: 35263605
DOI: 10.1016/j.celrep.2022.110469

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