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Article

The Choice of Search Engine Affects Sequencing Depth and HLA Class I Allele-Specific Peptide Repertoires.

Molecular & cellular proteomics : MCP - 1 Jan 2021

Parker Robert, Tailor Arun, Peng Xu, Nicastri Annalisa, Zerweck Johannes, Reimer Ulf, Wenschuh Holger, Schnatbaum Karsten, Ternette Nicola

Abstract excerpt

Standardization of immunopeptidomics experiments across laboratories is a pressing issue within the field, and currently a variety of different methods for sample preparation and data analysis tools are applied. Here, we compared different software packages to interrogate immunopeptidomics datasets and found that Peaks reproducibly reports substantially more peptide sequences (~30-70%) compared with Maxquant,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34303857
DOI: 10.1016/j.mcpro.2021.100124
PMCID: PMC8724928

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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