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Article

Mechanistic insight into bacterial entrapment by septin cage reconstitution.

Nature communications - 23 Jul 2021

Lobato-Márquez Damián, Xu Jingwei, Güler Gizem Özbaykal, Ojiakor Adaobi, Pilhofer Martin, Mostowy Serge

Abstract excerpt

Septins are cytoskeletal proteins that assemble into hetero-oligomeric complexes and sense micron-scale membrane curvature. During infection with Shigella flexneri, an invasive enteropathogen, septins restrict actin tail formation by entrapping bacteria in cage-like structures. Here, we reconstitute septin cages in vitro using purified recombinant septin complexes (SEPT2-SEPT6-SEPT7), and study how these...

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Identifiers

PMID: 34301939
DOI: 10.1038/s41467-021-24721-5
PMCID: PMC8302635

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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