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Article

Parallel in vivo experimental evolution reveals that increased stress resistance was key for the emergence of persistent tuberculosis bacilli.

Nature microbiology - 1 Aug 2021

Allen Aideen C, Malaga Wladimir, Gaudin Cyril, Volle Arnaud, Moreau Flavie, Hassan Ali, Astarie-Dequeker Catherine, Peixoto Antonio, Antoine Rudy, Pawlik Alexandre, Frigui Wafa, Berrone Céline, Brosch Roland, Supply Philip, Guilhot Christophe

Abstract excerpt

Pathogenomic evidence suggests that Mycobacterium tuberculosis (MTB) evolved from an environmental ancestor similar to Mycobacterium canettii, a rare human pathogen. Although the adaptations responsible for this transition are poorly characterized, the ability to persist in humans seems to be important. We set out to identify the adaptations contributing to the evolution of persistence in MTB. We performed an...

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PMID: 34294904
DOI: 10.1038/s41564-021-00938-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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