Multiregional sequencing and circulating tumour DNA analysis provide complementary approaches for comprehensive disease profiling of small lymphocytic lymphoma.

doi:10.1111/bjh.17718

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Article

Multiregional sequencing and circulating tumour DNA analysis provide complementary approaches for comprehensive disease profiling of small lymphocytic lymphoma.

British journal of haematology - 1 Oct 2021

Moia Riccardo, Favini Chiara, Ferri Valentina, Forestieri Gabriela, Terzi Di Bergamo Lodovico, Schipani Mattia, Sagiraju Sruthi, Andorno Annalisa, Rasi Silvia, Adhinaveni Ramesh, Talotta Donatella, Al Essa Wael, De Paoli Lorenzo, Margiotta Casaluci Gloria, Patriarca Andrea, Boldorini Renzo L, Rossi Davide, Gaidano Gianluca

Abstract excerpt

We aimed at molecularly dissecting the anatomical heterogeneity of small lymphocytic lymphoma (SLL), by analysing a cohort of 12 patients for whom paired DNA from a lymph node biopsy and circulating cells, as well as plasma-circulating tumour DNA (ctDNA) was available. Notably, the analyses of the lymph node biopsy and of circulating cells complement each other since a fraction of mutations (20·4% and 36·4%,...

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PMID: 34291829
DOI: 10.1111/bjh.17718
PMCID: PMC8519153

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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