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Article

An integrative study of genetic variants with brain tissue expression identifies viral etiology and potential drug targets of multiple sclerosis.

Molecular and cellular neurosciences - 1 Sept 2021

Manuel Astrid M, Dai Yulin, Freeman Leorah A, Jia Peilin, Zhao Zhongming

Abstract excerpt

Multiple sclerosis (MS) is a neuroinflammatory disorder leading to chronic disability. Brain lesions in MS commonly arise in normal-appearing white matter (NAWM). Genome-wide association studies (GWAS) have identified genetic variants associated with MS. Transcriptome alterations have been observed in case-control studies of NAWM. We developed a Cross-Dataset Evaluation (CDE) function for our network-based tool,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34284104
DOI: 10.1016/j.mcn.2021.103656
PMCID: PMC8802913

Genes

CDK4
IFITM3
MAPK1
MAPK3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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