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Multiomics integration prioritizes potential drug targets for multiple sclerosis

27 Jun 2025

Abstract excerpt

Multiple sclerosis (MS) is an immune-mediated disease with no current cure. Drug discovery and repurposing are essential to enhance treatment efficacy and safety. We utilized summary statistics for protein quantitative trait loci (pQTL) of 2,004 plasma and 1,443 brain proteins, a genome-wide association study of MS susceptibility with 14,802 cases and 26,703 controls, both bulk and cell-type specific...

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PMID: 40577117
DOI: 10.1073/pnas.2425537122

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