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Article

Potential of Telomerase in Age-Related Macular Degeneration-Involvement of Senescence, DNA Damage Response and Autophagy and a Key Role of PGC-1α.

International journal of molecular sciences - 3 Jul 2021

Blasiak Janusz, Szczepanska Joanna, Fila Michal, Pawlowska Elzbieta, Kaarniranta Kai

Abstract excerpt

Age-related macular degeneration (AMD), the main cause of vision loss in the elderly, is associated with oxidation in the retina cells promoting telomere attrition. Activation of telomerase was reported to improve macular functions in AMD patients. The catalytic subunit of human telomerase (hTERT) may directly interact with proteins important for senescence, DNA damage response, and autophagy, which are impaired...

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Source

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Identifiers

PMID: 34281248
DOI: 10.3390/ijms22137194
PMCID: PMC8268995

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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