Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mechanical Strain Drives Myeloid Cell Differentiation Toward Proinflammatory Subpopulations

17 Jul 2021

Abstract excerpt

Objective: After injury, humans and other mammals heal by forming fibrotic scar tissue with diminished function, and this healing process involves the dynamic interplay between resident cells within the skin and cells recruited from the circulation. Recent studies have provided mounting evidence that external mechanical forces stimulate intracellular signaling pathways to drive fibrotic processes.

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cellular Mechanics and Interactions
Share to Mesenchymal stem cell research
Share to Wound Healing and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34278820
DOI: 10.1089/wound.2021.0036

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mechanical Strain Drives Myeloid Cell Differentiation Toward Proinflammatory SubpopulationsPMID 34278820Read ↗

Shear Stress Induces a Time-Dependent Inflammatory Response in Human Monocyte-Derived MacrophagesSemantic proximity Read ↗

Macrophage Mechano-Responsiveness Within Three-Dimensional Tissue Matrix upon Mechanotherapy-Associated Strains.Semantic proximity Read ↗

Biophysical regulation of macrophages in health and diseaseSemantic proximity Read ↗

The effects of mechanical force on fibroblast behavior in cutaneous injurySemantic proximity Read ↗

Mechanoregulation of the Myofibroblast in Wound Contraction, Scarring, and Fibrosis: Opportunities for New Therapeutic InterventionSemantic proximity Read ↗

Biomechanical Forces Promote Immune Regulatory Function of Bone Marrow Mesenchymal Stromal Cells.Semantic proximity Read ↗

Wound Healing: A Cellular PerspectiveSemantic proximity Read ↗

The Myofibroblast Fate of Therapeutic Mesenchymal Stromal Cells: Regeneration, Repair, or Despair?Semantic proximity Read ↗

Human adipose mesenchymal stem cells modulate myeloid cells toward an anti-inflammatory and reparative phenotype: role of IL-6 and PGE2.Semantic proximity Read ↗

The mechanobiology of fibroblast activation in diseaseSemantic proximity Read ↗

Insights into the Anti-Inflammatory Effects of Soft Tissue ManipulationSemantic proximity Read ↗

Regulation of Chondrocytic Gene Expression by Biomechanical SignalsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.