Article
Biomechanical Forces Promote Immune Regulatory Function of Bone Marrow Mesenchymal Stromal Cells.
Stem cells (Dayton, Ohio) - 1 May 2017
Diaz Miguel F, Vaidya Abishek B, Evans Siobahn M, Lee Hyun J, Aertker Benjamin M, Alexander Alexander J, Price Katherine M, Ozuna Joyce A, Liao George P, Aroom Kevin R, Xue Hasen, Gu Liang, Omichi Rui, Bedi Supinder, Olson Scott D, Cox Charles S, Wenzel Pamela L
Abstract excerpt
Mesenchymal stromal cells (MSCs) are believed to mobilize from the bone marrow in response to inflammation and injury, yet the effects of egress into the vasculature on MSC function are largely unknown. Here we show that wall shear stress (WSS) typical of fluid frictional forces present on the vascular lumen stimulates antioxidant and anti-inflammatory mediators, as well as chemokines capable of immune cell...
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