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Article

Novel and functional ATG12 gene variants in sporadic Parkinson's disease.

Neuroscience letters - 16 Mar 2017

Li Yuequn, Huang Jian, Pang Shuchao, Wang Haihua, Zhang Aimei, Hawley Robert G, Yan Bo

Abstract excerpt

Parkinson's disease (PD) is a common and progressive neurodegenerative disease, including familial and sporadic cases. To date, genetic causes for sporadic PD, majority of PD cases, remain largely unknown. Accumulating evidence indicates that dysfunctional autophagy, a highly conserved cellular process, is involved in the PD pathogenesis. We speculated that changed expression levels of autophagy-related genes...

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Source

Identifiers

PMID: 28229934
DOI: 10.1016/j.neulet.2017.02.028

Genes

ATG12
ATG5
ATG7

Provenance

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