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Detection of EGFR mutations in liquid biopsy samples using allele-specific quantitative PCR: A comparative real-world evaluation of two popular diagnostic systems.

Advances in medical sciences - 1 Sept 2021

Szpechcinski Adam, Bryl Maciej, Wojcik Piotr, Czyzewicz Grzegorz, Wojda Emil, Rudzinski Piotr, Duk Katarzyna, Moes-Sosnowska Joanna, Maszkowska-Kopij Krystyna, Langfort Renata, Barinow-Wojewodzki Aleksander, Chorostowska-Wynimko Joanna

Abstract excerpt

PURPOSE: The detection of epidermal growth factor receptor (EGFR) mutations in plasma cell-free DNA (cfDNA) is an auxiliary tool for the molecular diagnosis of non-small cell lung cancer (NSCLC), especially when an adequate tumor tissue specimen cannot be obtained. We compared the diagnostic accuracy of two commonly used in vitro diagnostic-certified allele-specific quantitative PCR assays for detecting plasma...

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PMID: 34274564
DOI: 10.1016/j.advms.2021.06.003

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