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Article

Genetically Determined TSH Level Within Reference Range Is Inversely Associated With Alzheimer Disease.

The Journal of clinical endocrinology and metabolism - 19 Nov 2021

Li Gloria Hoi-Yee, Cheung Ching-Lung, Cheung Elaine Yun-Ning, Chan Wai-Chi, Tan Kathryn Choon-Beng

Abstract excerpt

CONTEXT: Contradictory findings were reported in observational studies on the association of thyroid function (thyrotropin [TSH] and free thyroxine [FT4] levels) with Alzheimer disease (AD). OBJECTIVE: This work aims to determine whether genetically determined TSH/FT4 levels within reference range are causally associated with AD. METHODS: A bidirectional, 2-sample mendelian randomization (MR) study was conducted....

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Identifiers

PMID: 34272859
DOI: 10.1210/clinem/dgab527

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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