Article
EBV-positive HIV-associated diffuse large B cell lymphomas are characterized by JAK/STAT (STAT3) pathway mutations and unique clinicopathologic features.
British journal of haematology - 1 Sept 2021
Chapman Jennifer R, Bouska Alyssa C, Zhang Weiwei, Alderuccio Juan Pablo, Lossos Izidore S, Rimsza Lisa M, Maguire Alanna, Yi Shuhua, Chan Wing C, Vega Francisco, Song Joo Y
Abstract excerpt
Even in the era of highly active combination antiretroviral therapy (cART), patients with HIV have a disproportionate risk of developing aggressive lymphomas that are frequently Epstein-Barr virus (EBV)-related. Here, we investigate HIV-associated diffuse large B-cell lymphoma (HIV-DLBCL) and compare EBV-positive and EBV-negative cases. HIV-DLBCL were identified from two academic medical centres and characterised...
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