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Article

Mutational profiling of HIV+ diffuse large B-cell lymphoma reveals distinct mutational features with evidence of genomic instability.

AIDS (London, England) - 1 Jun 2026

Roush Sophia M, Beck Samantha, Coelho Jenny, Chirwa Amon, Mponda Marriam, Kasonkanji Edwards, Mulenga Maurice, Tomoka Tamiwe, Vensko Steven, Merchant Akil, Xu Alexander M, Wang Jeremy R, Galeotti Jonathan, Gopal Satish, Yates Melinda, Broaddus Russell, Painschab Matthew S, Fedoriw Yuri

Abstract excerpt

BACKGROUND: People with HIV (PWH) remain underrepresented in molecular studies and clinical trials of diffuse large B-cell lymphoma (DLBCL), despite DLBCL being a leading cause of cancer-related death in this population. METHODS: We performed whole-exome sequencing on 30 DLBCL tumors (24 with paired germline) from a Malawian cohort including both HIV-positive (HIV+) and HIV-negative (HIV-) individuals. RESULTS:...

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Share to DNA Mutational Analysis
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41556969
DOI: 10.1097/QAD.0000000000004443
PMCID: PMC12981551

Genes

ARID1A
KMT2D
LILRB1
MSH2
MYD88
NRAS
PTEN
TP53

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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