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Article

Shared genomic features of HIV+ diffuse large B-cell lymphoma in two African cohorts.

Scientific reports - 9 Jul 2025

Roush Sophia M, Moodley Mishalan, Coelho Jenny, Beck Samantha, Chirwa Amon, Kasonkanji Edwards, Mponda Marriam, Mulenga Maurice, Tomoka Tamiwe, van Zijl Hanri, Hodkinson Katherine, Ismail Arshad, Mtshali Senzo, Featherston Jonathan, Gopal Satish, Painschab Matthew S, Vaughan Jenifer, Fedoriw Yuri

Abstract excerpt

The number of people with HIV (PWH) in Africa is rising due to population growth and antiretroviral therapy (ART) availability, with diffuse large B-cell lymphoma (DLBCL) a major cause of mortality. HIV and ART alter DLBCL tumor biology, but few studies of DLBCL include PWH or African patients, limiting translation of emerging treatment strategies. Here, we performed whole exome sequencing of 48 tumors (40...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40634688
DOI: 10.1038/s41598-025-10529-6
PMCID: PMC12241603

Genes

ARID1A
PMS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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