Reconciling functional differences in populations of neurons recorded with two-photon imaging and electrophysiology.

doi:10.7554/eLife.69068

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Article

Reconciling functional differences in populations of neurons recorded with two-photon imaging and electrophysiology.

eLife - 16 Jul 2021

Siegle Joshua H, Ledochowitsch Peter, Jia Xiaoxuan, Millman Daniel J, Ocker Gabriel K, Caldejon Shiella, Casal Linzy, Cho Andy, Denman Daniel J, Durand Séverine, Groblewski Peter A, Heller Gregg, Kato India, Kivikas Sara, Lecoq Jérôme, Nayan Chelsea, Ngo Kiet, Nicovich Philip R, North Kat, Ramirez Tamina K, Swapp Jackie, Waughman Xana, Williford Ali, Olsen Shawn R, Koch Christof, Buice Michael A, de Vries Saskia Ej

Abstract excerpt

Extracellular electrophysiology and two-photon calcium imaging are widely used methods for measuring physiological activity with single-cell resolution across large populations of cortical neurons. While each of these two modalities has distinct advantages and disadvantages, neither provides complete, unbiased information about the underlying neural population. Here, we compare evoked responses in visual cortex...

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PMID: 34270411
DOI: 10.7554/eLife.69068
PMCID: PMC8285106

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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