Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

BRAF mutation is rare in advanced-stage low-grade ovarian serous carcinomas.

The American journal of pathology - 1 Oct 2010

Wong Kwong-Kwok, Tsang Yvonne T M, Deavers Michael T, Mok Samuel C, Zu Zhifei, Sun Charlotte, Malpica Anais, Wolf Judith K, Lu Karen H, Gershenson David M

Abstract excerpt

Low-grade ovarian serous carcinomas are believed to arise via an adenoma-serous borderline tumor-serous carcinoma sequence. In this study, we found that advanced-stage, low-grade ovarian serous carcinomas both with and without adjacent serous borderline tumor shared similar regions of loss of heterozygosity. We then analyzed 91 ovarian tumor samples for mutations in TP53, BRAF, and KRAS. TP53 mutations were not...

Topics

Join the communities discussing this publication.

Biomarkers, Tumor
Cystadenocarcinoma, Serous
Genome, Human
Oligonucleotide Array Sequence Analysis
Ovarian Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Proto-Oncogene Proteins B-raf

Source

Open in PubMed Open full text

Identifiers

PMID: 20802181
DOI: 10.2353/ajpath.2010.100212
PMCID: PMC2947258

Genes

BRAF
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

BRAF mutation is rare in advanced-stage low-grade ovarian serous carcinomas.PMID 20802181Read ↗

In ovarian neoplasms, BRAF, but not KRAS, mutations are restricted to low-grade serous tumours.Semantic proximity Read ↗

Low‐grade serous carcinomas of the ovary contain very few point mutationsSemantic proximity Read ↗

Mutations of BRAF and KRAS precede the development of ovarian serous borderline tumors.Semantic proximity Read ↗

Low-grade serous ovarian cancer: A review.Semantic proximity Read ↗

Spectrum of BRAF Mutations and Gene Rearrangements in Ovarian Serous Carcinoma.Semantic proximity Read ↗

Mutation Profiles of Ovarian Seromucinous Borderline Tumors in Japanese Patients.Semantic proximity Read ↗

Patterns of p53 mutations separate ovarian serous borderline tumors and low- and high-grade carcinomas and provide support for a new model of ovarian carcinogenesis: a mutational analysis with immunohistochemical correlation.Semantic proximity Read ↗

Mutations in BRAF and KRAS characterize the development of low-grade ovarian serous carcinoma.Semantic proximity Read ↗

Low-grade serous ovarian carcinoma: an evolution toward targeted therapy.Semantic proximity Read ↗

A multistep model for ovarian tumorigenesis: the value of mutation analysis in the KRAS and BRAF genes.Semantic proximity Read ↗

Ovarian low-grade and high-grade serous carcinoma: pathogenesis, clinicopathologic and molecular biologic features, and diagnostic problems.Semantic proximity Read ↗

Origins and molecular pathology of ovarian cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.