Article
Low frequency of BRAF and KRAS mutations in Chinese patients with low-grade serous carcinoma of the ovary.
Diagnostic pathology - 22 Dec 2017
Xu Yan, Bi Rui, Xiao Yaoxing, Tu Xiaoyu, Li Ming, Li Anqi, Shan Ling, Zhou Shuling, Yang Wentao
Abstract excerpt
BACKGROUND: Mounting evidence has shown that KRAS and BRAF are somatic mutations associated with low grade serous carcinoma (LGSC) of the ovary. However, the frequency of KRAS or BRAF mutation was variable in literatures, with a frequency of 16-54% for KRAS mutation and 2-33% for BRAF mutation. Meanwhile, the prognostic significance of KRAS or BRAF mutation remains controversial. METHODS: Codons 12 and 13 of exon...
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