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Elephant seal muscle cells adapt to sustained glucocorticoid exposure by shifting their metabolic phenotype.

American journal of physiology. Regulatory, integrative and comparative physiology - 1 Sept 2021

Torres-Velarde Julia María, Kolora Sree Rohit Raj, Khudyakov Jane I, Crocker Daniel E, Sudmant Peter H, Vázquez-Medina José Pablo

Abstract excerpt

Elephant seals experience natural periods of prolonged food deprivation while breeding, molting, and undergoing postnatal development. Prolonged food deprivation in elephant seals increases circulating glucocorticoids without inducing muscle atrophy, but the cellular mechanisms that allow elephant seals to cope with such conditions remain elusive. We generated a cellular model and conducted transcriptomic,...

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PMID: 34260302
DOI: 10.1152/ajpregu.00052.2021

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