Global Gene Expression Profiling of Pleural Mesotheliomas: Overexpression of Aurora Kinases and <i>P16/CDKN2A</i> Deletion as Prognostic Factors and Critical Evaluation of Microarray-Based Prognostic Prediction

Abstract excerpt

Most gene expression profiling studies of mesothelioma have been based on relatively small sample numbers, limiting their statistical power. We did Affymetrix U133A microarray analysis on 99 pleural mesotheliomas, in which multivariate analysis showed advanced-stage, sarcomatous histology and P16/CDKN2A homozygous deletion to be significant independent adverse prognostic factors. Comparison of the expression...

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