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Article

Tumor Mutation Burden Predicts Relapse in Papillary Thyroid Carcinoma With Changes in Genes and Immune Microenvironment.

Frontiers in endocrinology - 1 Jan 2021

Guo Mengli, Chen Zhen, Li Yayi, Li Sijin, Shen Fei, Gan Xiaoxiong, Feng Jianhua, Cai Wensong, Liu Qingzhi, Xu Bo

Abstract excerpt

Background: The risk factors of papillary thyroid carcinoma (PTC) recurrence are meaningful for patients and clinicians. Tumor mutation burden (TMB) has been a biomarker for the effectiveness of immune checkpoint inhibitor (ICI) and prognosis in cancer. However, the role of TMB and its latent significance with immune cell infiltration in PTC are still unclear. Herein, we aimed to explore the effect of TMB on PTC...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lymphocytes, Tumor-Infiltrating

Share to Neoplasm Recurrence, Local

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Share to Thyroid Cancer, Papillary

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Source

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Identifiers

PMID: 34248843
DOI: 10.3389/fendo.2021.674616
PMCID: PMC8261145

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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