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Article

Immune gene signature delineates a subclass of thyroid cancer with unfavorable clinical outcomes.

Aging - 2 Apr 2020

Zhi Jingtai, Yi Jiaoyu, Tian Mengran, Wang Huijuan, Kang Ning, Zheng Xiangqian, Gao Ming

Abstract excerpt

Thyroid cancer (THCA) is a heterogeneous disease with multiple clinical outcomes Immune cells regulate its progression. Three immunomolecular subtypes (C1, C2, C3) were identified in gene expression data sets from TCGA and GEO databases. Among them, subtype C3 had highest frequency of BRAF mutations, lowest frequency of RAS mutations, highest mutation load and shorter progression-free survival. Functional...

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Share to Biomarkers, Tumor
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins B-raf

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Source

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Identifiers

PMID: 32240105
DOI: 10.18632/aging.102963
PMCID: PMC7185138

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