N-3 PUFA supplementation in adulthood modulates diet-induced depressive-like phenotype in female rats.

doi:10.1016/j.pnpbp.2025.111362

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Article

N-3 PUFA supplementation in adulthood modulates diet-induced depressive-like phenotype in female rats.

Progress in neuro-psychopharmacology & biological psychiatry - 20 Jun 2025

Palmieri Maria Adelaide, Agosti Lisa Pia, Bove Maria, Sikora Vladyslav, Santoro Martina, Tucci Paolo, Schiavone Stefania, Trabace Luigia, Morgese Maria Grazia

Abstract excerpt

Low consumption of omega-3 polyunsaturated fatty acids (n-3 PUFA) during development has been linked to increased risk of developing depressive symptoms. The present study assesses the influence of chronic n-3 PUFA supplementation in a rodent model of depressive-like phenotype induced by long-life depletion of n-3 PUFA in the diet. These behavioural and biological consequences already start to become apparent in...

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Topics

Animals
Female
Fatty Acids, Omega-3
Rats, Wistar
Rats
Dietary Supplements

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Depression

Phenotype

Hippocampus

Brain-Derived Neurotrophic Factor

Disease Models, Animal

Prefrontal Cortex

Diet

Pregnancy

Source

Open in PubMed

Identifiers

PMID: 40222644
DOI: 10.1016/j.pnpbp.2025.111362

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