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Article

GV-971 Ameliorates Chronic Restraint Stress-Induced Depression-like Phenotypes Accompanied by Reshaping of the Microbiota-Gut-Brain Axis.

Marine drugs - 24 May 2026

He Zhuandi, Nie Yali, Li Changcai, Sun Guangqiang, Zheng Wei, Liu Hongchun, Geng Meiyu, Tian Jingwei, Zhang Yu

Abstract excerpt

Depression is increasingly linked to microbiota-gut-brain axis dysfunction, yet current monoaminergic antidepressants show limited efficacy. This study investigated the therapeutic potential and underlying mechanisms of GV-971, a marine-derived oligosaccharide, in a chronic restraint stress (CRS) mouse model. We first established that 8 h of daily restraint for 4-8 weeks induces a stable depression-like phenotype...

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Identifiers

PMID: 42346775
DOI: 10.3390/md24060189
PMCID: PMC13301036

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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