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Article

NELL2-cdc42 signaling regulates BAF complexes and Ewing sarcoma cell growth.

Cell reports - 6 Jul 2021

Jayabal Panneerselvam, Zhou Fuchun, Lei Xiufen, Ma Xiuye, Blackman Barron, Weintraub Susan T, Houghton Peter J, Shiio Yuzuru

Abstract excerpt

BAF chromatin remodeling complexes play important roles in chromatin regulation and cancer. Here, we report that Ewing sarcoma cells are dependent on the autocrine signaling mediated by NELL2, a secreted glycoprotein that has been characterized as an axon guidance molecule. NELL2 uses Robo3 as the receptor to transmit critical growth signaling. NELL2 signaling inhibits cdc42 and upregulates BAF complexes and...

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Share to Oncogene Proteins, Fusion
Share to AC133 Antigen

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to cdc42 GTP-Binding Protein

Share to Chromatin Assembly and Disassembly

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Share to Proto-Oncogene Protein c-fli-1

Share to RNA-Binding Protein EWS

Share to Sarcoma, Ewing

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Identifiers

PMID: 34233189
DOI: 10.1016/j.celrep.2021.109254
PMCID: PMC8312579

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