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Article

Biomechanical cues as master regulators of hematopoietic stem cell fate

7 Jul 2021

Abstract excerpt

Hematopoietic stem cells (HSCs) perceive both soluble signals and biomechanical inputs from their microenvironment and cells themselves. Emerging as critical regulators of the blood program, biomechanical cues such as extracellular matrix stiffness, fluid mechanical stress, confined adhesiveness, and cell-intrinsic forces modulate multiple capacities of HSCs through mechanotransduction. In recent years, research...

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PMID: 34232331
DOI: 10.1007/s00018-021-03882-y

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