Article
Oncogenic cooperation between TCF7-SPI1 and NRAS(G12D) requires β-catenin activity to drive T-cell acute lymphoblastic leukemia.
Nature communications - 6 Jul 2021
Van Thillo Quentin, De Bie Jolien, Seneviratne Janith A, Demeyer Sofie, Omari Sofia, Balachandran Anushree, Zhai Vicki, Tam Wai L, Sweron Bram, Geerdens Ellen, Gielen Olga, Provost Sarah, Segers Heidi, Boeckx Nancy, Marshall Glenn M, Cheung Belamy B, Isobe Kiyotaka, Kato Itaru, Takita Junko, Amos Timothy G, Deveson Ira W, McCalmont Hannah, Lock Richard B, Oxley Ethan P, Garwood Maximilian M, Dickins Ross A, Uyttebroeck Anne, Carter Daniel R, Cools Jan, de Bock Charles E
Abstract excerpt
Spi-1 Proto-Oncogene (SPI1) fusion genes are recurrently found in T-cell acute lymphoblastic leukemia (T-ALL) cases but are insufficient to drive leukemogenesis. Here we show that SPI1 fusions in combination with activating NRAS mutations drive an immature T-ALL in vivo using a conditional bone marrow transplant mouse model. Addition of the oncogenic fusion to the NRAS mutation also results in a higher leukemic...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.