Article
Recurrent SPI1 (PU.1) fusions in high-risk pediatric T cell acute lymphoblastic leukemia.
Nature genetics - 1 Aug 2017
Seki Masafumi, Kimura Shunsuke, Isobe Tomoya, Yoshida Kenichi, Ueno Hiroo, Nakajima-Takagi Yaeko, Wang Changshan, Lin Lin, Kon Ayana, Suzuki Hiromichi, Shiozawa Yusuke, Kataoka Keisuke, Fujii Yoichi, Shiraishi Yuichi, Chiba Kenichi, Tanaka Hiroko, Shimamura Teppei, Masuda Kyoko, Kawamoto Hiroshi, Ohki Kentaro, Kato Motohiro, Arakawa Yuki, Koh Katsuyoshi, Hanada Ryoji, Moritake Hiroshi, Akiyama Masaharu, Kobayashi Ryoji, Deguchi Takao, Hashii Yoshiko, Imamura Toshihiko, Sato Atsushi, Kiyokawa Nobutaka, Oka Akira, Hayashi Yasuhide, Takagi Masatoshi, Manabe Atsushi, Ohara Akira, Horibe Keizo, Sanada Masashi, Iwama Atsushi, Mano Hiroyuki, Miyano Satoru, Ogawa Seishi, Takita Junko
Abstract excerpt
The outcome of treatment-refractory and/or relapsed pediatric T cell acute lymphoblastic leukemia (T-ALL) is extremely poor, and the genetic basis for this is not well understood. Here we report comprehensive profiling of 121 cases of pediatric T-ALL using transcriptome and/or targeted capture sequencing, through which we identified new recurrent gene fusions involving SPI1 (STMN1-SPI1 and TCF7-SPI1). Cases...
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