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Biological Basis for Syphilis

1 Jan 2006

Abstract excerpt

Syphilis is a chronic sexually transmitted disease caused by Treponema pallidum subsp. pallidum. Clinical manifestations separate the disease into stages; late stages of disease are now uncommon compared to the preantibiotic era. T. pallidum has an unusually small genome and lacks genes that encode many metabolic functions and classical virulence factors. The organism is extremely sensitive to environmental...

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PMID: 16418521
DOI: 10.1128/cmr.19.1.29-49.2006

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